Betanin as a multipath oxidative stress and inflammation modulator: a beetroot pigment with protective effects on cardiovascular disease pathogenesis

Oxidative Stress and Inflammation in Cardiovascular Disease

Oxidative Stress and Human Disease: a Review

Background: The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free rad...

Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis

The current study aimed to examine the renoprotective effects of long-term treatment with sodium hydrosulfide (NaHS), a prominent hydrogen sulfide donor, in 5/6 nephrectomy animal model. Twenty-four rats were randomly divided into 3 groups including sham-operated group (Sham), 5/6-nephrectomized group (5/6 Nx), and NaHS-treated group (5/6Nx+NaHS). NaHS (30 micromol/l) was added twice daily into...

Dalteparin as a Novel Therapeutic Agent to Prevent Diabetic Encephalopathy by Targeting Oxidative Stress and Inflammation

Introduction: Hepcidin is the principal modulator of systemic iron metabolism, and its role in the brain has been clarified recently. Studies have shown hepcidin plays an important role for in neuronal iron load and inflammation. This is of significance because neuronal iron load and inflammation are pathophysiological processes that have been highly linked to neurodegeneration. Moreover, the a...

Oxidative stress as a mediator of cardiovascular disease

During physiological processes molecules undergo chemical changes involving reducing and oxidizing reactions. A molecule with an unpaired electron can combine with a molecule capable of donating an electron. The donation of an electron is termed as oxidation whereas the gaining of an electron is called reduction. Reduction and oxidation can render the reduced molecule unstable and make it free ...